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Nebivolol is a long acting cardioselective beta-blocker currently licensed for the treatment of high blood pressure. Nebivolol, (bystolic, nebilet, nebil) is available in marketplace with names of Bystolic, Nebilet, Nebil. To know more about Nebivolol Uses and Side Effects and Symptoms of Diabetes visit these hyperlinks.

It has mild vasodilating properties attributed to its interaction with the L-arginine/nitric oxide pathway, a property not shared by other beta-blockers like Atenolol. Up to now this has been demonstrated in volunteers and small numbers of individuals.

If this mechanism is shown to lead to improved clinical outcomes, nebivolol, (bystolic, nebilet, nebil) could possibly be of worth in managing hypertensive patients with endothelial dysfunction eg those with diabetes or hypercholesterolaemia and in patients with ischaemic heart disease.

It is an efficient antihypertensive agent. Shortterm period up to 12 weeks. published medical studies in sufferers with mild essential high blood pressure have proven that it lowers sitting systolic and diastolic blood pressure to a similar extent as standard therapies -atenolol, metoprolol, enalapril, lisinopril, nifedipine and hydrochlorothiazide. One open, non-comparative study showed that a significant reduction in BP is maintained over 1 year.

It is well tolerated; the frequency and severity of adverse events is similar to that reported for placebo, atenolol or enalapril in published scientific studies. Within the largest comparative research the numbers of sufferers complaining of fatigue was smaller for nebivolol, (bystolic, nebilet, nebil) in contrast with atenolol, though the numbers in each groups were too small for any meaningful comparisons to be made. Additionally, in single comparative studies with nifedipine or metoprolol, the overall incidence of adverse events was smaller in the nebivolol, (bystolic, nebilet, nebil) groups.

Though uncontrolled Left Ventricular failure is listed as a contra-indication within the SPC, preliminary studies have shown that nebivolol has helpful effects on left ventricular function in patients with hypertension and heart failure.

Nebivolol, (bystolic, nebilet, nebil) is considerably more expensive than blockium, however costs lower than carvedilol or celiprolol.

ADVERSE EFFECTS
Nebivolol, (bystolic, nebilet, nebil) has been studied in over 3000 patients with high blood pressure, who have received the drug for not less than one month, and some for three years . The most frequent adverse events (incidence between 1-10%) had been headache, dizziness, tiredness and paraesthesia. Additional adverse events reported by a minimum of 1% of sufferers were: diarrhoea, constipation, nausea, dyspnoea and oedema . Other adverse events have been reported with a frequency of lower than 1% of patients of high blood pressure.

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One Response to “Nebivolol- Another Excellent Beta Blocker For High Blood Pressure”

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